Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid
نویسندگان
چکیده
منابع مشابه
Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid.
Eicosapentaenoic acid [20 : 5 (n-3)] is not oxidized by the purified cyclooxygenase from sheep vesicular glands in the conditions of low peroxide tone in which arachidonate [20 : 4 (n-6)] is rapidly oxygenated. When the level of peroxide in incubation mixtures is allowed to rise, there is a dramatic change in reactivity of the cyclooxygenase to react with 20 : 5 (n-3) at one-halt the rate and o...
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Received October 24, 1978 Summary : Cyclooxygenase catalysis is stimulated by its product, PGG2, and by other lipid hydroperoxides. The endoperoxide, PGH , was not stimulatory. The results provide a direct demonstration of an essen & ial role for lipid hydroperoxides in prostaglandin biosynthesis, and show how the biosynthetic intermediate PGG2 has a positive accelerative effect. INTRODUCTION A...
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ژورنال
عنوان ژورنال: Prostaglandins and Medicine
سال: 1979
ISSN: 0161-4630
DOI: 10.1016/0161-4630(79)90068-5